Journal article
Yi Li, H. Yang, Thavasyappan Thambi, Jae-Hyung Park, D. S. Lee
Biomaterials, 2019
Biomaterials, 2019
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DOI
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APA
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Li, Y., Yang, H., Thambi, T., Park, J.-H., & Lee, D. S. (2019). Charge-convertible polymers for improved tumor targeting and enhanced therapy. Biomaterials.
Chicago/Turabian
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Li, Yi, H. Yang, Thavasyappan Thambi, Jae-Hyung Park, and D. S. Lee. “Charge-Convertible Polymers for Improved Tumor Targeting and Enhanced Therapy.” Biomaterials (2019).
MLA
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Li, Yi, et al. “Charge-Convertible Polymers for Improved Tumor Targeting and Enhanced Therapy.” Biomaterials, 2019.
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@article{yi2019a,
title = {Charge-convertible polymers for improved tumor targeting and enhanced therapy.},
year = {2019},
journal = {Biomaterials},
author = {Li, Yi and Yang, H. and Thambi, Thavasyappan and Park, Jae-Hyung and Lee, D. S.}
}
Abstract
Charge-convertible polymers are a class of intelligent polymers that can convert their charges in response to a certain stimulus in their environment. This unique property endows charge-convertible polymer-based biomaterials with great advantages in the treatment of disease. Drug-loaded charge-convertible polymeric nanoparticles have the ability to target tumor cells by converting their surface charges from negative or neutral to positive at the tumor site. In addition, charge-convertible polymeric biomaterials can form complexes with negatively charged therapeutic agents and release them through charge conversion at the desired time and site. In this review, the properties of charge-convertible polymers and their applications in the treatment of cancer and stroke are covered. More importantly, the limitations and perspectives of charge-convertible polymeric biomaterials in future clinical applications are discussed.