At our lab, we develop advanced biomaterials for therapeutic, drug, and vaccine delivery. Our research centers on polymeric nanoparticles, microparticles, hydrogels, and supramolecular systems engineered for controlled, targeted, and responsive biomedical applications.
We combine biomaterials engineering, polymer chemistry, colloidal design, and transport science to create multifunctional platforms for challenges in nanomedicine, immunotherapy, and regenerative medicine. A major focus of our work is establishing structure–property–performance relationships that guide the rational design of smarter and more effective delivery systems.
We are also interested in immune-modulating biomaterials, injectable therapeutic systems, and regenerative scaffolds that can enhance tissue repair and improve clinical outcomes. Our mission is to bridge fundamental biomaterials research with translational strategies for next-generation healthcare technologies.
To address these challenges, our research is organized into several key areas focusing on the design and application of advanced biomaterial systems.
We combine biomaterials engineering, polymer chemistry, colloidal design, and transport science to create multifunctional platforms for challenges in nanomedicine, immunotherapy, and regenerative medicine. A major focus of our work is establishing structure–property–performance relationships that guide the rational design of smarter and more effective delivery systems.
We are also interested in immune-modulating biomaterials, injectable therapeutic systems, and regenerative scaffolds that can enhance tissue repair and improve clinical outcomes. Our mission is to bridge fundamental biomaterials research with translational strategies for next-generation healthcare technologies.
To address these challenges, our research is organized into several key areas focusing on the design and application of advanced biomaterial systems.
1. Regenerative Biomaterials and Tissue Engineering
We develop advanced hydrogel and composite biomaterial systems for tissue regeneration, with a particular focus on wound healing, vascularization, and functional tissue repair. Our research integrates hyaluronic acid-based hydrogels, polymeric networks, and bioactive composite scaffolds engineered to mimic the extracellular matrix (ECM) and support dynamic tissue environments.
We design stimuli-responsive and biodegradable biomaterials with multifunctional properties, including antibacterial activity, hemostasis, exudate management, and controlled therapeutic delivery. By incorporating bioactive components such as proteins, nanomaterials, and drugs, our systems promote cell proliferation, angiogenesis, and accelerated tissue remodeling.
Through in vitro and in vivo studies, we demonstrate the ability of these platforms to enhance wound closure, tissue integration, and regenerative outcomes, highlighting their strong potential for translational biomedical applications.
We develop advanced hydrogel and composite biomaterial systems for tissue regeneration, with a particular focus on wound healing, vascularization, and functional tissue repair. Our research integrates hyaluronic acid-based hydrogels, polymeric networks, and bioactive composite scaffolds engineered to mimic the extracellular matrix (ECM) and support dynamic tissue environments.
We design stimuli-responsive and biodegradable biomaterials with multifunctional properties, including antibacterial activity, hemostasis, exudate management, and controlled therapeutic delivery. By incorporating bioactive components such as proteins, nanomaterials, and drugs, our systems promote cell proliferation, angiogenesis, and accelerated tissue remodeling.
Through in vitro and in vivo studies, we demonstrate the ability of these platforms to enhance wound closure, tissue integration, and regenerative outcomes, highlighting their strong potential for translational biomedical applications.
2. Biomaterials for Immunomodulation and Vaccine Delivery
We develop biomaterial-based platforms for immune modulation and vaccine delivery, focusing on polymeric nanoparticles, supramolecular hydrogels, and hybrid systems. Our goal is to enhance antigen delivery, immune cell targeting, and controlled activation of immune responses.
Our systems are designed for efficient uptake by antigen-presenting cells (APCs) and to promote both humoral and cellular immunity, including CD4⁺ and CD8⁺ T cell responses. We place particular emphasis on mucosal and intranasal delivery strategies for non-invasive vaccination and improved immune protection.
We also engineer injectable supramolecular hydrogels for cancer immunotherapy, capable of inducing ROS-mediated tumor apoptosis and activating key pathways (caspase, Bax/Bcl-2, p53), while modulating the tumor microenvironment through cytokine regulation. By integrating adjuvants and stimuli-responsive biomaterials, these platforms enable dendritic cell maturation, immune activation, and tumor suppression, with strong potential for vaccines and immunotherapy.
Our systems are designed for efficient uptake by antigen-presenting cells (APCs) and to promote both humoral and cellular immunity, including CD4⁺ and CD8⁺ T cell responses. We place particular emphasis on mucosal and intranasal delivery strategies for non-invasive vaccination and improved immune protection.
We also engineer injectable supramolecular hydrogels for cancer immunotherapy, capable of inducing ROS-mediated tumor apoptosis and activating key pathways (caspase, Bax/Bcl-2, p53), while modulating the tumor microenvironment through cytokine regulation. By integrating adjuvants and stimuli-responsive biomaterials, these platforms enable dendritic cell maturation, immune activation, and tumor suppression, with strong potential for vaccines and immunotherapy.
3. Smart Hydrogels for Controlled and Responsive Systems
We develop injectable and stimuli-responsive hydrogels with dynamic properties for controlled drug delivery and biomedical applications. These systems are engineered to respond to environmental triggers such as temperature, pH, ions, or biomolecules, enabling precise and on-demand therapeutic release.
Our research integrates nanocomposite and hybrid hydrogel systems with tunable mechanical strength, gelation behavior, and swelling characteristics. These platforms exhibit excellent injectability, shape adaptability, and biocompatibility, making them suitable for minimally invasive applications.
We further demonstrate their potential through sustained drug release, enhanced therapeutic efficacy, and in vivo performance, highlighting their applications in cancer therapy, tissue repair, and regenerative medicine.
Our research integrates nanocomposite and hybrid hydrogel systems with tunable mechanical strength, gelation behavior, and swelling characteristics. These platforms exhibit excellent injectability, shape adaptability, and biocompatibility, making them suitable for minimally invasive applications.
We further demonstrate their potential through sustained drug release, enhanced therapeutic efficacy, and in vivo performance, highlighting their applications in cancer therapy, tissue repair, and regenerative medicine.
4. Oral Delivery of Biologics Using Hydrogel Beads
We develop hydrogel bead-based systems for oral delivery of biologics, including proteins, peptides (e.g., insulin), and nutraceutical compounds. These platforms are designed to protect sensitive cargos from harsh gastric conditions and enable controlled release in the intestinal environment.
Our systems utilize core–shell and composite hydrogel beads with tunable structure and crosslinking density to achieve pH-responsive behavior, sustained release, and enhanced stability. By integrating bioactive components and nanomaterials, we improve encapsulation efficiency, targeted release, and therapeutic performance.
These platforms demonstrate strong potential for applications in oral therapeutics, metabolic disease management, and nutraceutical delivery, offering a non-invasive alternative to conventional administration routes.
Our systems utilize core–shell and composite hydrogel beads with tunable structure and crosslinking density to achieve pH-responsive behavior, sustained release, and enhanced stability. By integrating bioactive components and nanomaterials, we improve encapsulation efficiency, targeted release, and therapeutic performance.
These platforms demonstrate strong potential for applications in oral therapeutics, metabolic disease management, and nutraceutical delivery, offering a non-invasive alternative to conventional administration routes.
5. Polymeric Nanoparticles for Targeted Drug Delivery
We develop polymeric nanoparticle systems for targeted and controlled drug delivery, with a focus on improving drug stability, bioavailability, and tumor-specific accumulation. Our platforms are engineered to respond to tumor microenvironmental cues, enabling precise and efficient therapeutic delivery.
Our research emphasizes stimuli-responsive nanoparticles, including systems sensitive to hypoxia, redox conditions, and other biological triggers, to achieve controlled drug release at the disease site. These nanoparticles facilitate enhanced cellular uptake, intracellular delivery, and therapeutic efficacy.
We further validate these systems through in vivo imaging, biodistribution studies, and tumor inhibition models, demonstrating improved targeting efficiency and anticancer performance, highlighting their potential for precision nanomedicine applications.