Journal article
Dong Wook Kim, T. Le, S. M. Lee, H. Kim, Yoon‐Joo Ko, J. Jeong, Thavasyappan Thambi, D. S. Lee, S. U. Son
2020
2020
Semantic Scholar
DOI
Cite
Cite
APA
Click to copy
Kim, D. W., Le, T., Lee, S. M., Kim, H., Ko, Y. J., Jeong, J., … Son, S. U. (2020). Microporous Organic Nanoparticles Anchoring CeO
2
Materials: Reduced Toxicity and Efficient Reactive Oxygen Species‐Scavenging for Regenerative Wound Healing.
Chicago/Turabian
Click to copy
Kim, Dong Wook, T. Le, S. M. Lee, H. Kim, Yoon‐Joo Ko, J. Jeong, Thavasyappan Thambi, D. S. Lee, and S. U. Son. “Microporous Organic Nanoparticles Anchoring CeO
2
Materials: Reduced Toxicity and Efficient Reactive Oxygen Species‐Scavenging for Regenerative Wound Healing” (2020).
MLA
Click to copy
Kim, Dong Wook, et al. Microporous Organic Nanoparticles Anchoring CeO
2
Materials: Reduced Toxicity and Efficient Reactive Oxygen Species‐Scavenging for Regenerative Wound Healing. 2020.
BibTeX Click to copy
@article{dong2020a,
title = {Microporous Organic Nanoparticles Anchoring CeO
2
Materials: Reduced Toxicity and Efficient Reactive Oxygen Species‐Scavenging for Regenerative Wound Healing},
year = {2020},
author = {Kim, Dong Wook and Le, T. and Lee, S. M. and Kim, H. and Ko, Yoon‐Joo and Jeong, J. and Thambi, Thavasyappan and Lee, D. S. and Son, S. U.}
}
Abstract
This work shows that microporous organic polymer can be applied to the engineering of CeO2-based antioxidant nanomaterials for in vivo regenerative wound healing. Whilst nanoparticulate CeO2 has shown excellent redox quenching of reactive oxygen species (ROS) because it is rich in oxygen defects and Ce species, it has a strong tendency to form aggregates because it is a kinetic intermediate of bulk materials. Anchoring of nanoparticulate CeO2 on suitable supports can be an efficient anti-aggregation strategy. In this work, CeO2 nanoparticles were immobilized on microporous organic nanoparticles (MONPs) to form MONP@CeO2 nanocomposites. Compared to CeO2 materials, the MONP@CeO2 nanocomposites showed not only efficient ROS scavenging in in vivo regenerative wound healing but also reduced cytotoxicity in in vitro cell studies, due to the efficient distribution and dilution effect of CeO2 nanomaterials.