Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses

Thavasyappan Thambi; Jinwoo Hong; A. Yoon; C. Yun

Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses

Journal article

Thavasyappan Thambi, Jinwoo Hong, A. Yoon, C. Yun
Cancer Gene Therapy, 2022

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Thambi, T., Hong, J., Yoon, A., & Yun, C. (2022). Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses. Cancer Gene Therapy.

Chicago/Turabian Click to copy
Thambi, Thavasyappan, Jinwoo Hong, A. Yoon, and C. Yun. “Challenges and Progress toward Tumor-Targeted Therapy by Systemic Delivery of Polymer-Complexed Oncolytic Adenoviruses.” Cancer Gene Therapy (2022).

MLA Click to copy
Thambi, Thavasyappan, et al. “Challenges and Progress toward Tumor-Targeted Therapy by Systemic Delivery of Polymer-Complexed Oncolytic Adenoviruses.” Cancer Gene Therapy, 2022.

BibTeX Click to copy

@article{thavasyappan2022a,
  title = {Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses},
  year = {2022},
  journal = {Cancer Gene Therapy},
  author = {Thambi, Thavasyappan and Hong, Jinwoo and Yoon, A. and Yun, C.}
}

Abstract

Oncolytic adenovirus (oAd) elicits antitumor activity by preferential viral replication in cancer cells. However, poor systemic administrability or suboptimal intratumoral retainment of the virus remains a major challenge toward maximizing the antitumor activity of oAd in a clinical environment. To surmount these issues, a variety of non-immunogenic polymers has been used to modify the surface of oAds chemically or physically. Complexation of oAd with polymers can effectively evade the host immune response and reduces nonspecific liver sequestration. The tumor-specific delivery of these complexes can be further improved upon by inclusion of tumor-targeting moieties on the surface. Therefore, modification of the Ad surface using polymers is viewed as a potential strategy to enhance the delivery of Ad via systemic administration. This review aims to provide a comprehensive overview of polymer-complexed Ads, their progress, and future challenges in cancer treatment.