Journal article
Cuong Hung Luu, G. Nguyen, T. Le, Thanh-Mai Ngoc Nguyen, V. H. Giang Phan, Mohanapriya Murugesan, Ramya Mathiyalagan, Lu Jing, Gopinathan Janarthanan, D. Yang, Yi Li, Thavasyappan Thambi
Gels, 2022
Gels, 2022
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DOI
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APA
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Luu, C. H., Nguyen, G., Le, T., Nguyen, T.-M. N., Phan, V. H. G., Murugesan, M., … Thambi, T. (2022). Graphene Oxide-Reinforced Alginate Hydrogel for Controlled Release of Local Anesthetics: Synthesis, Characterization, and Release Studies. Gels.
Chicago/Turabian
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Luu, Cuong Hung, G. Nguyen, T. Le, Thanh-Mai Ngoc Nguyen, V. H. Giang Phan, Mohanapriya Murugesan, Ramya Mathiyalagan, et al. “Graphene Oxide-Reinforced Alginate Hydrogel for Controlled Release of Local Anesthetics: Synthesis, Characterization, and Release Studies.” Gels (2022).
MLA
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Luu, Cuong Hung, et al. “Graphene Oxide-Reinforced Alginate Hydrogel for Controlled Release of Local Anesthetics: Synthesis, Characterization, and Release Studies.” Gels, 2022.
BibTeX Click to copy
@article{cuong2022a,
title = {Graphene Oxide-Reinforced Alginate Hydrogel for Controlled Release of Local Anesthetics: Synthesis, Characterization, and Release Studies},
year = {2022},
journal = {Gels},
author = {Luu, Cuong Hung and Nguyen, G. and Le, T. and Nguyen, Thanh-Mai Ngoc and Phan, V. H. Giang and Murugesan, Mohanapriya and Mathiyalagan, Ramya and Jing, Lu and Janarthanan, Gopinathan and Yang, D. and Li, Yi and Thambi, Thavasyappan}
}
Abstract
In pain relief, lidocaine has gained more attention as a local anesthetic. However, there are several side effects that limit the use of local anesthetics. Therefore, it is hypothesized that a hydrogel system with facile design can be used for prolonged release of lidocaine. In this study, we developed a formulation comprises of sodium alginate (SA) and graphene oxide (GO) to prolong the release of lidocaine. The gelation was induced by physically crosslinking the alginate with Ca2+ ions. The formation of blank SA and GO-reinforced SA hydrogels was investigated with different concentration of Ca2+ ions. The controlled release of lidocaine hydrochloride (LH) on both hydrogel systems was studied in PBS solution. The GO-reinforced SA hydrogels exhibited more sustained release than SA hydrogels without GO. In vitro biocompatibility test in L929 fibroblast cells confirmed the non-toxic property of hydrogels. Furthermore, to prove the in-situ gelation and biodegradability of hydrogels the hydrogels were injected on mice model and confirmed the stable gel formation. The hydrogels implanted onto the subcutaneous tissue of hydrogels retained over one week. These results indicate that LH-loaded GO-reinforced SA hydrogel can be a potential biomaterial for controlled release of local anesthetics.