APA
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Nguyen, N. T., Nguyen, B.-P. T., Ho, T., Tran, C.-N. D., Tran, T.-H. H., Nguyen, H.-P. H., … Thambi, T. (2024). Orally ingestible medication utilizing layered double hydroxide nanoparticles strengthened alginate and hyaluronic acid-based hydrogel bead for bowel disease management. International Journal of Biological Macromolecules.
Chicago/Turabian
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Nguyen, Ngoc Tuan, Bich-Phuong Thi Nguyen, Tuyet Ho, Cam-Nhung Dinh Tran, Thanh-Han Hoang Tran, Hoai-Phong Huu Nguyen, Hong-Phuc Nguyen, et al. “Orally Ingestible Medication Utilizing Layered Double Hydroxide Nanoparticles Strengthened Alginate and Hyaluronic Acid-Based Hydrogel Bead for Bowel Disease Management.” International Journal of Biological Macromolecules (2024).
MLA
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Nguyen, Ngoc Tuan, et al. “Orally Ingestible Medication Utilizing Layered Double Hydroxide Nanoparticles Strengthened Alginate and Hyaluronic Acid-Based Hydrogel Bead for Bowel Disease Management.” International Journal of Biological Macromolecules, 2024.
BibTeX Click to copy
@article{ngoc2024a,
title = {Orally ingestible medication utilizing layered double hydroxide nanoparticles strengthened alginate and hyaluronic acid-based hydrogel bead for bowel disease management.},
year = {2024},
journal = {International Journal of Biological Macromolecules},
author = {Nguyen, Ngoc Tuan and Nguyen, Bich-Phuong Thi and Ho, Tuyet and Tran, Cam-Nhung Dinh and Tran, Thanh-Han Hoang and Nguyen, Hoai-Phong Huu and Nguyen, Hong-Phuc and Huynh, Ngoc-Thuy and Li, Yi and Phan, V. and Thambi, Thavasyappan}
}
In the treatment of bowel diseases such as ulcerative colitis through oral administration, an effective drug delivery system targeting the colon is crucial for enhancing efficacy and minimizing side effects of therapeutic agents. This study focuses on the development of a novel nanocomposite hydrogel bead comprising a synergistic blend of biological macromolecules, namely sodium alginate (ALG) and hyaluronic acid (HA), reinforced with layered double hydroxide nanoparticles (LDHs) for the oral delivery of dual therapeutics. The synthesized hydrogel bead exhibits significantly enhanced gel strength and controllable release of methylprednisolone (MP) and curcumin (CUR), serving as an anti-inflammatory drug and a mucosal healing agent, compared to native ALG or ALG/HA hydrogel beads without LDHs. The physicochemical properties of the synthesized LDHs and hydrogel beads were characterized using various techniques, including scanning electron microscopy, zeta potential measurement, transmission electron microscopy, X-ray diffraction, and energy-dispersive X-ray spectroscopy. In vitro release studies of MP and CUR under simulated gastrointestinal tract (GIT) conditions demonstrate the superior controlled release property of the nanocomposite hydrogel bead, particularly in minimizing premature drug release in the upper GIT environment while sustaining release of over 82 % of drugs in the colonic environment. Thus, the modularly engineered carrier designed for oral colon targeting holds promise as a potential candidate for the treatment of ulcerative colitis.